Marinho et al., published the first-ever report using optical coherence tomography to evaluate the retina in Covid-19 patients. In Hubei province a total of 12 of 38 patients had ocular manifestations. SARS-CoV have been found in tears of patients even without conjunctivitis [2]. Coronavirus (CoVs) infection requires Angiotensin Converting Enzyme-2 (ACE2) receptor, followed by its priming by host cell transmembrane protease, serine 2 (TMPRSS2). Both ACE2 and TMPRSS2 are ubiquitously present not only on the conjunctiva and cornea, but also inside the eye trabecular meshwork, aqueous humor, iris, ciliary body, non-pigmented ciliary epithelium, and retina [4]. Hence, a question arises: Can be considered an ocular route for SARS-CoV-2 to invade the brain? The presence of the ACE2 receptors and TMPRSS2 protein on the corneal limbal stem cells may theoretically allow the SARS-CoV-2 to cross the ocular surface, and then entering the nervous system via the ophthalmic branch of trigeminal nerve. Moreover, the use of viruses driving expression of fluorescent proteins has been used for tracing neural connections, spreading from postsynaptic to presynaptic neurons.