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Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS-CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant — National Healthcare Safety Network, March 1–August 1, 2021

Srinivas Nanduri, MD1,*; Tamara Pilishvili, PhD1,*; Gordana Derado, PhD1; Minn Minn Soe, MBBS1; Philip Dollard, MPH1; Hsiu Wu, MD1; Qunna Li, MSPH1; Suparna Bagchi, DrPH1; Heather Dubendris, MSPH1,2; Ruth Link-Gelles, PhD1; John A. Jernigan, MD1; Daniel Budnitz, MD1; Jeneita Bell, MD1; Andrea Benin, MD1; Nong Shang, PhD1; Jonathan R. Edwards, MStat1,*; Jennifer R. Verani, MD1,*; Stephanie J. Schrag, DPhil1
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What is already known about this topic?

Early observational studies among nursing home residents showed mRNA vaccines to be 53% to 92% effective against SARS-CoV-2 infection.

What is added by this report?

Two doses of mRNA vaccines were 74.7% effective against infection among nursing home residents early in the vaccination program (March–May 2021). During June–July 2021, when B.1.617.2 (Delta) variant circulation predominated, effectiveness declined significantly to 53.1%.

What are the implications for public health practice?

Multicomponent COVID-19 prevention strategies, including vaccination of nursing home staff members, residents, and visitors, are critical. An additional dose of COVID-19 vaccine might be considered for nursing home and long-term care facility residents to optimize a protective immune response.
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Publicado en el sitio 2021-09-05 20:43:23
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