Mass vaccination of Israeli adults with the BNT162b2 vaccine has been associated with a substantially lower rate of SARS-CoV-2 infection.¹ After the vaccination program, the Centers for Disease Control and Prevention eliminated the need for quarantine after exposure.² However, there are still cases of SARS-CoV-2 infection among fully vaccinated individuals.^3,4 We studied the possible association between exposure characteristics and infection risk among vaccinated and nonvaccinated health care workers (HCWs) in Israel.